Molecular characterization of invasive Streptococcus dysgalactiae subsp. Equisimilis, Japan

Takeaki Wajima, Miyuki Morozumi, Shigeo Hanada, Katsuhiko Sunaoshi, Naoko Chiba, Satoshi Iwata, Kimiko Ubukata

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38 Citations (Scopus)


We collected β-hemolytic streptococci (1,611 isolates) from patients with invasive streptococcal infections in Japan during April 2010–March 2013. Streptococcus dysgalactiae subsp. equisimilis (SDSE) was most common (n = 693); 99%m of patients with SDSE infections were elderly (mean age 75 years, SD ±15 years). We aimed to clarify molecular and epidemiologic characteristics of SDSE isolates and features of patient infections. Bacteremia with no identified focus of origin and cellulitis were the most prevalent manifestations; otherwise, clinical manifestations resembled those of S. pyogenes infections. Clinical manifestations also differed by patient’s age. SDSE isolates were classified into 34 emm types; stG6792 was most prevalent (27.1%), followed by stG485 and stG245. Mortality rates did not differ according to emm types. Multilocus sequence typing identified 46 sequence types and 12 novel types. Types possessing macrolide-and quinolone-resistance genes were 18.4% and 2.6%, respectively; none showed blactam resistance. Among aging populations, invasive SDSE infections are an increasing risk.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalEmerging Infectious Diseases
Issue number2
Publication statusPublished - 2016 Feb

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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