Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

Kazunobu Toshima; Ryusuke Takano; Tomohiro Ozawa; Shuichi Matsumura

doi:10.1039/b107829c

Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

Kazunobu Toshima, Ryusuke Takano, Tomohiro Ozawa, Shuichi Matsumura

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

184 Citations (Scopus)

Abstract

Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5′ side guanine of 5′-GG-3′ site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline-carbohydrate) hybrid system was very effective for DNA cleavage.

Original language	English
Pages (from-to)	212-213
Number of pages	2
Journal	Chemical Communications
Volume	2
Issue number	3
DOIs	https://doi.org/10.1039/b107829c
Publication status	Published - 2002 Jan 1

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5′ side guanine of 5′-GG-3′ site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline-carbohydrate) hybrid system was very effective for DNA cleavage.",

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AU - Matsumura, Shuichi

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AB - Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5′ side guanine of 5′-GG-3′ site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline-carbohydrate) hybrid system was very effective for DNA cleavage.

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Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

Abstract

ASJC Scopus subject areas

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