Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism

Yuuki Imai, Takashi Nakamura, Takahiro Matsumoto, Kunio Takaoka, Shigeaki Kato

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


The multifarious functions of sex steroid receptors include a role as regulatory factors for bone and mineral metabolism in vivo. These functions are more complex than originally assumed. The finding of nuclear receptors in osseous tissue alludes to the existence of novel indirect and direct functions of bone tissue beyond skeletal support, hematopoiesis, and calcium homeostasis. Cell-specific gene targeting approaches are an extremely important technology for future studies that will need to be conducted to fully understand the molecular mechanisms underlying bone formation and metabolism.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalJournal of Bone and Mineral Metabolism
Issue number2
Publication statusPublished - 2009 Mar
Externally publishedYes


  • Androgen receptor
  • Estrogen receptor
  • Osteoclast
  • Osteoporosis
  • Sex steroid hormone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


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