Monoclonal antibodies recognising pol and env proteins of mammalian retroviruses

Naoyuki Nishimura; Shingo Kato; Hiromichi Ishikawa; Toshiya Takano

doi:10.1159/000150270

Monoclonal antibodies recognising pol and env proteins of mammalian retroviruses

Naoyuki Nishimura, Shingo Kato, Hiromichi Ishikawa, Toshiya Takano

Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Mouse monoclonal antibodies were generated for three 20- to 23-mer synthetic peptides whose amino acid sequences were highly conserved in the pol or env regions of 14 mammalian and two avian retroviruses. By Western-blot analysis, these antibodies recognised the epitopes in major and minor pol or env proteins of six mammalian type-C and -D retroviruses. One of the anti-env monoclonal antibodies was found to recognise all the env transmembrane proteins of six mammalian retroviruses examined.

Original language	English
Pages (from-to)	112-116
Number of pages	5
Journal	Intervirology
Volume	34
Issue number	2
DOIs	https://doi.org/10.1159/000150270
Publication status	Published - 1992

Keywords

Baboon endogenous virus
Env protein
Human retrovirus
Monoclonal antibody
Pol protein
Retrovirus
Western-blot analysis

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000150270

Cite this

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abstract = "Mouse monoclonal antibodies were generated for three 20- to 23-mer synthetic peptides whose amino acid sequences were highly conserved in the pol or env regions of 14 mammalian and two avian retroviruses. By Western-blot analysis, these antibodies recognised the epitopes in major and minor pol or env proteins of six mammalian type-C and -D retroviruses. One of the anti-env monoclonal antibodies was found to recognise all the env transmembrane proteins of six mammalian retroviruses examined.",

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author = "Naoyuki Nishimura and Shingo Kato and Hiromichi Ishikawa and Toshiya Takano",

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AU - Nishimura, Naoyuki

AU - Kato, Shingo

AU - Ishikawa, Hiromichi

AU - Takano, Toshiya

PY - 1992

Y1 - 1992

N2 - Mouse monoclonal antibodies were generated for three 20- to 23-mer synthetic peptides whose amino acid sequences were highly conserved in the pol or env regions of 14 mammalian and two avian retroviruses. By Western-blot analysis, these antibodies recognised the epitopes in major and minor pol or env proteins of six mammalian type-C and -D retroviruses. One of the anti-env monoclonal antibodies was found to recognise all the env transmembrane proteins of six mammalian retroviruses examined.

AB - Mouse monoclonal antibodies were generated for three 20- to 23-mer synthetic peptides whose amino acid sequences were highly conserved in the pol or env regions of 14 mammalian and two avian retroviruses. By Western-blot analysis, these antibodies recognised the epitopes in major and minor pol or env proteins of six mammalian type-C and -D retroviruses. One of the anti-env monoclonal antibodies was found to recognise all the env transmembrane proteins of six mammalian retroviruses examined.

KW - Baboon endogenous virus

KW - Env protein

KW - Human retrovirus

KW - Monoclonal antibody

KW - Pol protein

KW - Retrovirus

KW - Western-blot analysis

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Monoclonal antibodies recognising pol and env proteins of mammalian retroviruses

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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