Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Haruhisa Kikuchi; Keisuke Ichinohe; Shinya Kida; Shinya Murase; Osamu Yamada; Yoshiteru Oshima

doi:10.1021/acs.orglett.6b03057

Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Haruhisa Kikuchi
, Keisuke Ichinohe
, Shinya Kida
, Shinya Murase
, Osamu Yamada
, Yoshiteru Oshima

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.

Original language	English
Pages (from-to)	5948-5951
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	22
DOIs	https://doi.org/10.1021/acs.orglett.6b03057
Publication status	Published - 2016 Nov 18
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.6b03057

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abstract = "A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.",

author = "Haruhisa Kikuchi and Keisuke Ichinohe and Shinya Kida and Shinya Murase and Osamu Yamada and Yoshiteru Oshima",

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AU - Kikuchi, Haruhisa

AU - Ichinohe, Keisuke

AU - Kida, Shinya

AU - Murase, Shinya

AU - Yamada, Osamu

AU - Oshima, Yoshiteru

PY - 2016/11/18

Y1 - 2016/11/18

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AB - A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.

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DO - 10.1021/acs.orglett.6b03057

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Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

Abstract

ASJC Scopus subject areas

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