Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation

Takashi Sasamura, Shigenobu Nakamura, Yuko Iida, Hideki Fujii, Jun Murata, Ikuo Saiki, Hiroshi Nojima, Yasushi Kuraishi

Research output: Contribution to journalArticlepeer-review

145 Citations (Scopus)

Abstract

The present study was conducted to clarify whether relief from cancer pain by morphine would suppress tumor growth and metastasis. When given orthotopic inoculation of B16-BL6 melanoma cells into the hind paw, C57BL/6 mice showed moderate and marked hyperalgesia on days 7-10 and from day 14 post-inoculation, respectively. The volume of inoculated hind paw was increased exponentially as a function of time from day 8 post-inoculation, a phenomena being due to melanoma growth. Lung metastasis was apparent after day 12 post-inoculation. On day 16 post-inoculation, the hyperalgesia was completely inhibited by subcutaneous injection of morphine hydrochloride (5 and 10 mg/kg). The tumor growth and lung metastasis were markedly inhibited by repeated administration of morphine (5 and 10 mg/kg daily for 6 days) and also by the neurectomy of sciatic nerve innervating the inoculated region. The results suggest that relief from cancer pain by morphine inhibits tumor growth and metastasis.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalEuropean journal of pharmacology
Volume441
Issue number3
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • (Mouse)
  • Cancer pain
  • Hyperalgesia
  • Morphine
  • Tumor growth
  • Tumor metastasis

ASJC Scopus subject areas

  • Pharmacology

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