MPAI (Mass Probes Aided Ionization) method for total analysis of biomolecules by mass spectrometry

Aki Honda; Shinichiro Hayashi; Hiroki Hifumi; Yuya Honma; Noriyuki Tanji; Naoko Iwasawa; Yoshio Suzuki; Koji Suzuki

doi:10.2116/analsci.23.11

MPAI (Mass Probes Aided Ionization) method for total analysis of biomolecules by mass spectrometry

Aki Honda, Shinichiro Hayashi, Hiroki Hifumi, Yuya Honma, Noriyuki Tanji, Naoko Iwasawa, Yoshio Suzuki, Koji Suzuki

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

We have designed and synthesized various mass probes, which enable us to effectively ionize various molecules to be detected with mass spectrometry. We call the ionization method using mass probes the "MPAI (mass probes aided ionization)" method. We aim at the sensitive detection of various biological molecules, and also the detection of biomolecules by a single mass spectrometry serially without changing the mechanical settings. Here, we review mass probes for small molecules with various functional groups and mass probes for proteins. Further, we introduce newly developed mass probes for proteins for highly sensitive detection. 2007

Original language	English
Pages (from-to)	11-15
Number of pages	5
Journal	analytical sciences
Volume	23
Issue number	1
DOIs	https://doi.org/10.2116/analsci.23.11
Publication status	Published - 2007 Jan
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry

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AU - Honda, Aki

AU - Hayashi, Shinichiro

AU - Hifumi, Hiroki

AU - Honma, Yuya

AU - Tanji, Noriyuki

AU - Iwasawa, Naoko

AU - Suzuki, Yoshio

AU - Suzuki, Koji

PY - 2007/1

Y1 - 2007/1

N2 - We have designed and synthesized various mass probes, which enable us to effectively ionize various molecules to be detected with mass spectrometry. We call the ionization method using mass probes the "MPAI (mass probes aided ionization)" method. We aim at the sensitive detection of various biological molecules, and also the detection of biomolecules by a single mass spectrometry serially without changing the mechanical settings. Here, we review mass probes for small molecules with various functional groups and mass probes for proteins. Further, we introduce newly developed mass probes for proteins for highly sensitive detection. 2007

AB - We have designed and synthesized various mass probes, which enable us to effectively ionize various molecules to be detected with mass spectrometry. We call the ionization method using mass probes the "MPAI (mass probes aided ionization)" method. We aim at the sensitive detection of various biological molecules, and also the detection of biomolecules by a single mass spectrometry serially without changing the mechanical settings. Here, we review mass probes for small molecules with various functional groups and mass probes for proteins. Further, we introduce newly developed mass probes for proteins for highly sensitive detection. 2007

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JO - analytical sciences

JF - analytical sciences

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MPAI (Mass Probes Aided Ionization) method for total analysis of biomolecules by mass spectrometry

Abstract

ASJC Scopus subject areas

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