Multi-omics data-driven systems biology of E. coli

Nobuyoshi Ishii, Masaru Tomita

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Citations (Scopus)


The omics, which means comprehensive analysis of a specific layer in a cellular system, are emerging as essential methodological approaches for molecular biology and systems biology. However, single omics analysis does not always provide enough information to understand the behaviors of a cellular system. Therefore, a combination of multiple omics analyses, the multi-omics approach, is required to acquire a precise picture of living organisms. In this chapter, basic concepts of omics studies, and recent technologies in the omics of metabolism and published multi-omics analyses of Escherichia coli, are reviewed. Subsequently, a large-scale multi-omics analysis of E. coli K-12, including transcriptomics, proteomics, metabolomics and fluxomics, is presented. This study uncovered the complementary strategies of E. coli that result in a metabolic network robust against various types of perturbations, therefore demonstrating the power of a multi-omics, data-driven approach for understanding the functional principles of total cellular systems.

Original languageEnglish
Title of host publicationSystems Biology and Biotechnology of Escherichia coli
PublisherSpringer Netherlands
Number of pages17
ISBN (Print)9781402093937
Publication statusPublished - 2009 Dec 1

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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