Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6)

Tomoyuki Hishida; Masahiro Tsuboi; Takehito Shukuya; Kazuya Takamochi; Hiroyuki Sakurai; Kiyotaka Yoh; Yasuo Ohashi; Hideo Kunitoh

doi:10.1093/jjco/hyv028

Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6)

Tomoyuki Hishida, Masahiro Tsuboi, Takehito Shukuya, Kazuya Takamochi, Hiroyuki Sakurai, Kiyotaka Yoh, Yasuo Ohashi, Hideo Kunitoh

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Post-operative adjuvant chemotherapy has been considered an effective strategy to reduce cancer recurrence and improve survival for resected non-small-cell lung cancer. The Japan Clinical Oncology Group has completed patient accrual for a randomized Phase III study (JCOG0707), which compares the survival benefit of UFT and S-1 for completely resected pathological Stage I (T1 >2 cm and T2 in TNM classification version 6) non-small-cell lung cancer. However, there is a growing concern that those who participated in clinical trials are highly selected patients and do not represent the 'realworld' population. This multicenter observational cohort study aims to analyze the backgrounds, pattern of care and outcomes of the patients who were excluded from the JCOG0707 study during the accrual period. The results of this cohort study will be useful for external validity of the results of clinical trial such as JCOG0707.

Original language	English
Pages (from-to)	499-501
Number of pages	3
Journal	Japanese journal of clinical oncology
Volume	45
Issue number	5
DOIs	https://doi.org/10.1093/jjco/hyv028
Publication status	Published - 2015 May 1
Externally published	Yes

Keywords

Early stage
Non-small-cell lung cancer
Observational cohort study
Post-operative adjuvant chemotherapy
Randomized Phase III study

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jjco/hyv028

Cite this

Hishida, T., Tsuboi, M., Shukuya, T., Takamochi, K., Sakurai, H., Yoh, K., Ohashi, Y., & Kunitoh, H. (2015). Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6). Japanese journal of clinical oncology, 45(5), 499-501. https://doi.org/10.1093/jjco/hyv028

Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6). / Hishida, Tomoyuki; Tsuboi, Masahiro; Shukuya, Takehito et al.
In: Japanese journal of clinical oncology, Vol. 45, No. 5, 01.05.2015, p. 499-501.

Research output: Contribution to journal › Article › peer-review

Hishida, T, Tsuboi, M, Shukuya, T, Takamochi, K, Sakurai, H, Yoh, K, Ohashi, Y & Kunitoh, H 2015, 'Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6)', Japanese journal of clinical oncology, vol. 45, no. 5, pp. 499-501. https://doi.org/10.1093/jjco/hyv028

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abstract = "Post-operative adjuvant chemotherapy has been considered an effective strategy to reduce cancer recurrence and improve survival for resected non-small-cell lung cancer. The Japan Clinical Oncology Group has completed patient accrual for a randomized Phase III study (JCOG0707), which compares the survival benefit of UFT and S-1 for completely resected pathological Stage I (T1 >2 cm and T2 in TNM classification version 6) non-small-cell lung cancer. However, there is a growing concern that those who participated in clinical trials are highly selected patients and do not represent the 'realworld' population. This multicenter observational cohort study aims to analyze the backgrounds, pattern of care and outcomes of the patients who were excluded from the JCOG0707 study during the accrual period. The results of this cohort study will be useful for external validity of the results of clinical trial such as JCOG0707.",

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note = "Funding Information: This study is sponsored by the Comprehensive Support Project for Oncology Research (CSPOR) of Public Health Research Foundation. However, the funds for Study A are provided by Taiho Pharmaceutical Co., Ltd. according to a contract. The secretary for the CSPOR will perform the clerical work for the study but will not make decisions in association with planning, implementation, and publication of the study. Additionally, this study will be administered independent of the provider of the funds, and the provider of the funds will never be involved in the decision making for the planning, implementation, analysis and publication of the study. The decisions regarding the planning, implementation, and publication of the study will be made by the executive committee for the study. Publisher Copyright: {\textcopyright} The Author 2015. Published by Oxford University Press. All rights reserved.",

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Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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