Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern

M. Sakamoto; S. Hirohashi; H. Tsuda; Y. Shimosato; M. Makuuchi; Y. Hosoda

doi:10.1097/00000478-198912000-00009

Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern

M. Sakamoto, S. Hirohashi, H. Tsuda, Y. Shimosato, M. Makuuchi, Y. Hosoda

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

Two separate nodular lesions of hepatocellular carcinoma (HCC) were surgically removed from a patient with positive serum hepatitis B surface antigen. Southern blot analysis of DNA from the two separate HCC lesions showed different restriction patterns of integrated hepatitis B virus DNA, indicating their independent origins. The two lesions were composed mainly of poorly differentiated HCC; however, well-differentiated HCC was also observed in the periphery of the lesions. This histological findings is consistent with the multistep and independent development of HCC in each site of the liver.

Original language	English
Pages (from-to)	1064-1067
Number of pages	4
Journal	American Journal of Surgical Pathology
Volume	13
Issue number	12
DOIs	https://doi.org/10.1097/00000478-198912000-00009
Publication status	Published - 1989
Externally published	Yes

Keywords

Hepatitis B virus DNA
Hepatocellular carcinoma
Liver
Multicentric development

ASJC Scopus subject areas

Anatomy
Surgery
Pathology and Forensic Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00000478-198912000-00009

Cite this

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title = "Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern",

abstract = "Two separate nodular lesions of hepatocellular carcinoma (HCC) were surgically removed from a patient with positive serum hepatitis B surface antigen. Southern blot analysis of DNA from the two separate HCC lesions showed different restriction patterns of integrated hepatitis B virus DNA, indicating their independent origins. The two lesions were composed mainly of poorly differentiated HCC; however, well-differentiated HCC was also observed in the periphery of the lesions. This histological findings is consistent with the multistep and independent development of HCC in each site of the liver.",

keywords = "Hepatitis B virus DNA, Hepatocellular carcinoma, Liver, Multicentric development",

author = "M. Sakamoto and S. Hirohashi and H. Tsuda and Y. Shimosato and M. Makuuchi and Y. Hosoda",

year = "1989",

doi = "10.1097/00000478-198912000-00009",

language = "English",

volume = "13",

pages = "1064--1067",

journal = "American Journal of Surgical Pathology",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern

AU - Sakamoto, M.

AU - Hirohashi, S.

AU - Tsuda, H.

AU - Shimosato, Y.

AU - Makuuchi, M.

AU - Hosoda, Y.

PY - 1989

Y1 - 1989

N2 - Two separate nodular lesions of hepatocellular carcinoma (HCC) were surgically removed from a patient with positive serum hepatitis B surface antigen. Southern blot analysis of DNA from the two separate HCC lesions showed different restriction patterns of integrated hepatitis B virus DNA, indicating their independent origins. The two lesions were composed mainly of poorly differentiated HCC; however, well-differentiated HCC was also observed in the periphery of the lesions. This histological findings is consistent with the multistep and independent development of HCC in each site of the liver.

AB - Two separate nodular lesions of hepatocellular carcinoma (HCC) were surgically removed from a patient with positive serum hepatitis B surface antigen. Southern blot analysis of DNA from the two separate HCC lesions showed different restriction patterns of integrated hepatitis B virus DNA, indicating their independent origins. The two lesions were composed mainly of poorly differentiated HCC; however, well-differentiated HCC was also observed in the periphery of the lesions. This histological findings is consistent with the multistep and independent development of HCC in each site of the liver.

KW - Hepatitis B virus DNA

KW - Hepatocellular carcinoma

KW - Liver

KW - Multicentric development

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DO - 10.1097/00000478-198912000-00009

M3 - Article

C2 - 2556944

AN - SCOPUS:0024852676

SN - 0147-5185

VL - 13

SP - 1064

EP - 1067

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

IS - 12

ER -

Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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