Abstract
Two separate nodular lesions of hepatocellular carcinoma (HCC) were surgically removed from a patient with positive serum hepatitis B surface antigen. Southern blot analysis of DNA from the two separate HCC lesions showed different restriction patterns of integrated hepatitis B virus DNA, indicating their independent origins. The two lesions were composed mainly of poorly differentiated HCC; however, well-differentiated HCC was also observed in the periphery of the lesions. This histological findings is consistent with the multistep and independent development of HCC in each site of the liver.
| Original language | English |
|---|---|
| Pages (from-to) | 1064-1067 |
| Number of pages | 4 |
| Journal | American Journal of Surgical Pathology |
| Volume | 13 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1989 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Hepatitis B virus DNA
- Hepatocellular carcinoma
- Liver
- Multicentric development
ASJC Scopus subject areas
- Anatomy
- Surgery
- Pathology and Forensic Medicine
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