Multichannel biosensing and stimulation LSI chip using 0.18μm complementary metal-oxide-semiconductor technology

Masaya Yamaguchi, Akiyoshi Shimada, Keiichi Torimitsu, Nobuhiko Nakano

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We designed 8-channel preamplifiers and multisite stimulation circuits on a 2:5 ×; 1:4mm2 chip using a 0.18 μm complementary metal-oxide-semiconductor (CMOS) process for a microelectrode array measurement system. The size of a 1-channel preamplifier including a DC store/adder circuit is 930 ×120 μm2. An 8-channel programmable stimulator was integrated on the same die. The preamplifier circuits can amplify a small neural signal with a low noise and a low power consumption (2 mW/ch) using a chopper operation. The stimulation circuits can apply a voltage of ±700mV to any channel and with any timing using serial digital data control. The performance of the biphasic stimulation waveform generated by the designed LSI chip is the same as that generated with a conventional stimulation system. These functions were confirmed by connecting the LSI chip to a conventional measurement system. The system miniaturization achieved using the custom LSI chip will offer great advantages in terms of future brain machine interface applications.

Original languageEnglish
Article number04DL14
JournalJapanese journal of applied physics
Issue number4 PART 2
Publication statusPublished - 2010 Apr

ASJC Scopus subject areas

  • General Engineering
  • General Physics and Astronomy


Dive into the research topics of 'Multichannel biosensing and stimulation LSI chip using 0.18μm complementary metal-oxide-semiconductor technology'. Together they form a unique fingerprint.

Cite this