Multifractal feature descriptor for histopathology

Chamidu Atupelage, Hiroshi Nagahashi, Masahiro Yamaguchi, Michiie Sakamoto, Akinori Hashiguchi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background: Histologic image analysis plays an important role in cancer diagnosis. It describes the structure of the body tissues and abnormal structure gives the suspicion of the cancer or some other diseases. Observing the structural changes of these chaotic textures from the human eye is challenging process. However, the challenge can be defeat by forming mathematical descriptor to represent the histologic texture and classify the structural changes via a sophisticated computational method. Objective: In this paper, we propose a texture descriptor to observe the histologic texture into highly discriminative feature space. Method: Fractal dimension describes the self-similar structures in different and more accurate manner than topological dimension. Further, the fractal phenomenon has been extended to natural structures (images) as multifractal dimension. We exploited the multifractal analysis to represent the histologic texture, which derive more discriminative feature space for classification. Results: We utilized a set of histologic images (belongs to liver and prostate specimens) to assess the discriminative power of the multifractal features. The experiment was organized to classify the given histologic texture as cancer and non-cancer. The results show the discrimination capability of multifractal features by achieving approximately 95% of correct classification rate. Conclusion: Multifractal features are more effective to describe the histologic texture. The proposed feature descriptor showed high classification rate for both liver and prostate data sample datasets.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalAnalytical Cellular Pathology
Issue number2
Publication statusPublished - 2012


  • Histologic images
  • fractal
  • multifractal
  • texture classification

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Cell Biology
  • Cancer Research


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