Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects

Naoto Kuroda, Chisato Ohe, Shuji Mikami, Keiji Inoue, Yoji Nagashima, Ronald J. Cohen, Chin Chen Pan, Michal Michal, Ondrej Hes

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)


Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of varioussized cysts. The fibrous septa are generally thin and there is no discernible expansile nodule. Microscopically, the cyst walls are lined with tumor cells with clear to occasionally slightly eosinophilic cytoplasm. The Fuhrman nuclear grade is generally low and usually corresponds to grade 1. The deletion of chromosome 3p was identified in most tumors using FISH analysis and VHL gene mutation was identified in 25% of MCRCC. As MCRCC generally exhibits a low stage of TNM classification, the great majority of these tumors have a favorable clinical course. To date, there are no reports of metastasis, vascular invasion or sarcomatoid change in MCRCC. Accordingly, nephron sparing surgery is first recommended as a therapeutic strategy.

Original languageEnglish
Pages (from-to)969-974
Number of pages6
JournalHistology and Histopathology
Issue number8
Publication statusPublished - 2012 Aug
Externally publishedYes


  • Chromosome 3p
  • Clear cell renal cell carcinoma
  • Multilocular cystic renal cell carcinoma
  • VHL gene mutation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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