TY - JOUR
T1 - Multiple metastases of androgen indifferent prostate cancer in the urinary tract
T2 - two case reports and a literature review
AU - Masuda, Tsukasa
AU - Kosaka, Takeo
AU - Nakamura, Kohei
AU - Hongo, Hiroshi
AU - Yuge, Kazuyuki
AU - Nishihara, Hiroshi
AU - Oya, Mototsugu
N1 - Funding Information:
This study was supported in part by a Grant‐in‐Aid for Scientific Research (#20H03817 to T. Kosaka) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The study was supported in part by a research grant to T. Kosaka from the Fukuzawa Foundation of Keio University, Japan. The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: Prostate cancer (PC) is mainly known to metastasize to bone, lung and liver, but isolated metastases of prostate cancer, including ductal carcinoma, in the urinary tract are very rare. We describe two patients with nodular masses in the urinary tract (the anterior urethra or the urinary bladder) that were found on cystoscopy during treatment of castration-resistant prostate cancer. Case presentation: In both cases, the pathological diagnosis from transurethral tumor resection showed that they were androgen indifferent prostate cancer (AIPC), including aggressive variant prostate cancer (AVPC) in Case 1 and treatment-induced neuroendocrine differentiation prostate cancer (NEPC) in Case 2. In Case 1, Loss of genetic heterozygosity (LOH) of BRCA2 and gene amplification of KRAS was identified from the urethra polyps. In Case 2, homozygous deletion was observed in PTEN, and LOH without mutation was observed in RB1. Conclusion: These are the first reports of two cases of urinary tract metastasis of AIPC.
AB - Background: Prostate cancer (PC) is mainly known to metastasize to bone, lung and liver, but isolated metastases of prostate cancer, including ductal carcinoma, in the urinary tract are very rare. We describe two patients with nodular masses in the urinary tract (the anterior urethra or the urinary bladder) that were found on cystoscopy during treatment of castration-resistant prostate cancer. Case presentation: In both cases, the pathological diagnosis from transurethral tumor resection showed that they were androgen indifferent prostate cancer (AIPC), including aggressive variant prostate cancer (AVPC) in Case 1 and treatment-induced neuroendocrine differentiation prostate cancer (NEPC) in Case 2. In Case 1, Loss of genetic heterozygosity (LOH) of BRCA2 and gene amplification of KRAS was identified from the urethra polyps. In Case 2, homozygous deletion was observed in PTEN, and LOH without mutation was observed in RB1. Conclusion: These are the first reports of two cases of urinary tract metastasis of AIPC.
KW - AR
KW - Aggressive variant prostate cancer
KW - BRCA2
KW - Neuroendocrine differentiation prostate cancer
KW - PTEN
KW - TP53
KW - Urinary tract metastasis
UR - http://www.scopus.com/inward/record.url?scp=85130315127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85130315127&partnerID=8YFLogxK
U2 - 10.1186/s12920-022-01267-z
DO - 10.1186/s12920-022-01267-z
M3 - Article
C2 - 35598018
AN - SCOPUS:85130315127
SN - 1755-8794
VL - 15
JO - BMC Medical Genomics
JF - BMC Medical Genomics
IS - 1
M1 - 118
ER -
