Multisystem Imaging Manifestations of Kawasaki Disease

Yuko Tsujioka, Atsuhiko Handa, Gen Nishimura, Masaru Miura, Koji Yokoyama, Kozo Sato, Hideo Handa, Masahiro Jinzaki, Shunsuke Nosaka, Tatsuo Kono

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Kawasaki disease (KD) is a common pediatric vasculitis syndrome involving medium-and small-sized arteries that is especially preva-lent in early childhood (ie, age 6 months to 5 years). The diagnosis of KD is made on the basis of clinical features, such as fever, char-acteristic mucocutaneous changes, and nonsuppurative cervical lymphadenopathy. However, early diagnosis is often challenging because many children with KD present with atypical symptoms. The most serious complication of KD is coronary artery aneurysm caused by coronary arteritis. Prompt intravenous immunoglobu-lin therapy reduces the risk of cardiac morbidity. In addition, the systemic extension of KD-related vasculitis during the acute phase causes a variety of multisystem manifestations, including encepha-lopathy, stroke, retropharyngeal edema, pericarditis, myocarditis, KD shock syndrome, pulmonary lesions, intestinal pseudo-obstruc-tion, gallbladder hydrops, arthritis, and myositis. These complications tend to be more common in affected children with atypical presentation. Radiologists can play an important role in the timely identification of diverse KD-associated morbidities and thus may contribute to the early diagnosis of atypical KD.

Original languageEnglish
Pages (from-to)268-288
Number of pages21
Issue number1
Publication statusPublished - 2022 Jan 1

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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