TY - JOUR
T1 - Myopathy associated with antibodies to signal recognition particle
T2 - disease progression and neurological outcome.
AU - Suzuki, Shigeaki
AU - Hayashi, Yukiko K.
AU - Kuwana, Masataka
AU - Tsuburaya, Rie
AU - Suzuki, Norihiro
AU - Nishino, Ichizo
PY - 2012/6
Y1 - 2012/6
N2 - To characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy. Case series. Keio University Hospitals and National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. We reviewed clinical features of 27 patients with anti-SRP myopathy and analyzed disease progression and neurological outcome. Anti-SRP antibodies in serum were detected by RNA immunoprecipitation assay using extracts of K562 cells. Of the 27 patients, 5 (19%) showed chronic progressive muscle weakness as well as atrophy of limbs and trunk muscles from a younger age with more severe neurological outcomes compared with the other 22 patients(81%) with the subacute form. A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits.
AB - To characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy. Case series. Keio University Hospitals and National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. We reviewed clinical features of 27 patients with anti-SRP myopathy and analyzed disease progression and neurological outcome. Anti-SRP antibodies in serum were detected by RNA immunoprecipitation assay using extracts of K562 cells. Of the 27 patients, 5 (19%) showed chronic progressive muscle weakness as well as atrophy of limbs and trunk muscles from a younger age with more severe neurological outcomes compared with the other 22 patients(81%) with the subacute form. A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits.
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M3 - Article
C2 - 22332183
AN - SCOPUS:84865588381
SN - 0003-9942
VL - 69
SP - 728
EP - 732
JO - Archives of neurology
JF - Archives of neurology
IS - 6
ER -