Myopia Is Suppressed by Digested Lactoferrin or Holo-Lactoferrin Administration

Yifan Liang, Shin Ichi Ikeda, Junhan Chen, Yan Zhang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Myopia is becoming a leading cause of vision impairment. An effective intervention is needed. Lactoferrin (LF) is a protein that has been reported to inhibit myopia progression when taken orally. This study looked at the effects of different forms of LF, such as native LF and digested LF, on myopia in mice. Mice were given different forms of LF from 3 weeks of age, and myopia was induced with minus lenses from 4 weeks of age. Results showed that mice given digested LF or holo-LF had a less elongated axial length and thinned choroid, compared to those given native-LF. Gene expression analysis also showed that the groups given native-LF and its derivatives had lower levels of certain cytokines and growth factors associated with myopia. These results suggest that myopia can be more effectively suppressed by digested LF or holo-LF than native-LF.

Original languageEnglish
Article number5815
JournalInternational journal of molecular sciences
Issue number6
Publication statusPublished - 2023 Mar


  • choroid
  • holo-lactoferrin
  • lactoferricin
  • lactoferrin
  • myopia
  • sclera

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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