Nanoparticle-assisted laser desorption/ionization based mass imaging with cellular resolution

Shu Taira, Yuki Sugiura, Shinji Moritake, Shuichi Shimma, Yuko Ichiyanagi, Mitsutoshi Setou

Research output: Contribution to journalArticlepeer-review

129 Citations (Scopus)


Today, two-dimensional mass spectrometry analysis of biological tissues by means of a technique called mass imaging, mass spectrometry imaging (MSI), or imaging mass spectrometry (IMS) has found application in investigating the distribution of molecules - MSI with matrix-assisted laser desorption/ionization (MALDI) and secondary ion MS (SIMS). However, the size of the matrix crystal and the migration of analytes can decrease the spatial resolution in MALDI, and SIMS can only ionize compounds with relatively low molecular weights. To overcome these problems, we developed a nanoparticle-assisted laser desorption/ionization (nano-PALDI)-based MSI. We used nano-PALDI MSI to visualize lipids and peptides at a resolution of 15 μm in mammalian tissues.

Original languageEnglish
Pages (from-to)4761-4766
Number of pages6
JournalAnalytical chemistry
Issue number12
Publication statusPublished - 2008 Jun 15
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


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