NASH model-- role of interleukin-1 receptor

Shojiro Sawada, Hidetsugu Saito, Masatoshi Kusuhara

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Although the anti-inflammatory effect of interleukin-1 (IL-1) receptor antagonist (IL-1Ra) has been described, the contribution of this cytokine to non-alcoholic steatohepatitis (NASH) remains unclear. Our aim was to ascertain whether deficiency of IL-1Ra leads to hepatic inflammation and fibrosis upon consumption of an atherogenic diet. IL-1Ra deficient mice (IL-1Ra(-/-)) showed severe steatosis and pericellular fibrosis containing many inflammatory cells following 20 weeks of an atherogenic diet when compared with wild type (WT) mice. The hepatic histology of IL-1Ra(-/-) mice is similar to that of NASH.

Original languageEnglish
Pages (from-to)1063-1070
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number6
Publication statusPublished - 2006 Jun

ASJC Scopus subject areas

  • Medicine(all)


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