Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata

Kazuki Fujii, Yasumasa Hara, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A new coumarin derivative (1) and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata, guided by B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity. Among the isolated compounds, 15 compounds showed BMI1 promoter inhibitory activity, and five compounds were found to be cytotoxic. 14-Deoxy-11,12-dehydroandrographolide (18) was highly cytotoxic to DU145 cells with an IC50 value of 25.4µM. Western blotting analysis of compound 18 in DU145 cells suggested that compound 18 suppresses BMI1 expression.

Original languageEnglish
Pages (from-to)885-891
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume70
Issue number12
DOIs
Publication statusPublished - 2022 Dec 1

Keywords

  • Andrographis paniculata
  • B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity
  • Mammea siamensis
  • coumarin
  • labdane diterpene

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery

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