Natural compounds with Wnt signal modulating activity

Rolly G. Fuentes, Midori A. Arai, Masami Ishibashi

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)


Covering: up to 2015 The Wnt signalling pathway is essential in many biological processes. The Wnt signal is associated with several diseases, particularly cancer and neurodegenerative diseases. Recently, high-throughput screening systems have been developed to rapidly identify compounds, including natural compounds, that target the Wnt signal. Some studies on natural modulators of the Wnt signal have also suggested their possible target. This review highlights some important natural compounds reported to regulate Wnt activity and describes their possible mechanism of action.

Original languageEnglish
Pages (from-to)1622-1628
Number of pages7
JournalNatural Product Reports
Issue number12
Publication statusPublished - 2015 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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