Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1

Yuko Ehara, Osamu Yamamoto, Kenjiro Kosaki, Yuichi Yoshida

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Neurofibromatosis 1 (NF1) is characterized by cutaneous, neurological and osseous manifestations. Most NF1 patients develop cutaneous neurofibromas. However, time-dependent change with aging and the predilection site of cutaneous neurofibromas remain unclear. To clarify the natural course and characteristics of cutaneous neurofibromas, a retrospective study was conducted for 57 NF1 patients who were treated at the Department of Dermatology of Tottori University Hospital between January 2007 and April 2016. For each patient, we investigated the time-dependent changes and the numbers of cutaneous neurofibromas in four body surface regions. There was a positive correlation between age and number of cutaneous neurofibromas (r = 0.75, P < 0.001). Cutaneous neurofibromas were located on the trunk (60.2%), lower limbs (16.1%), upper limbs (14.4%), and head and neck (9.2%). There was no significant relationship between each body type (e.g. obese or thin) and cutaneous neurofibromas. With respect to the year-to-year percentage change in cutaneous neurofibromas, the average annual rate of increase was 0.21 (range, −0.71 to 1.2). The number of cutaneous neurofibromas had increased in approximately 61% of the patients 1 year later. Our data will enable physicians to estimate the overall state of cutaneous neurofibromas in NF1 and will be useful for handling cutaneous manifestations before they become a serious condition.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalJournal of Dermatology
Issue number1
Publication statusPublished - 2018 Jan


  • NF1
  • cutaneous neurofibroma
  • distribution
  • neurofibromatosis 1
  • predilection body site

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1'. Together they form a unique fingerprint.

Cite this