TY - GEN
T1 - Near Infrared Light-Triggerd on-Demand Drug Delivery from Non-Toxic Hydrogel Microbeads with Heat Transducer
AU - Takatsuka, Shuhei
AU - Kubota, Takeshi
AU - Kurashina, Yuta
AU - Onoe, Hiroaki
N1 - Publisher Copyright:
© 2021 IEEE.
PY - 2021/6/20
Y1 - 2021/6/20
N2 - This paper describes a near-infrared (NIR) light-triggered drug release system using alginate hydrogel microbeads. As a drug carrier, calcium alginate hydrogel microbeads encapsulating heat transducing particle (Fe304 particles) were fabricated by a centrifugal based fabrication method. The Fe304 particles instantly generate heat due to localized surface plasmon resonance when irradiated with NIR light. As a result, the calcium alginate hydrogel is thermally denatured to release a drug model. By irradiating NIR-laser to the hydrogel microbeads, we confirmed the release of fluorescent polystyrene particles ( 10 nm) as a drug model. This result indicates that the polymer network of the calcium alginate hydrogel responded to the heat at the molecular scale, even though calcium alginate hydrogel is generally stable to heat. This NIR light-triggered drug release system using Fe3O4 particles would be an effectiveand safe platform for on-demand drug delivery.
AB - This paper describes a near-infrared (NIR) light-triggered drug release system using alginate hydrogel microbeads. As a drug carrier, calcium alginate hydrogel microbeads encapsulating heat transducing particle (Fe304 particles) were fabricated by a centrifugal based fabrication method. The Fe304 particles instantly generate heat due to localized surface plasmon resonance when irradiated with NIR light. As a result, the calcium alginate hydrogel is thermally denatured to release a drug model. By irradiating NIR-laser to the hydrogel microbeads, we confirmed the release of fluorescent polystyrene particles ( 10 nm) as a drug model. This result indicates that the polymer network of the calcium alginate hydrogel responded to the heat at the molecular scale, even though calcium alginate hydrogel is generally stable to heat. This NIR light-triggered drug release system using Fe3O4 particles would be an effectiveand safe platform for on-demand drug delivery.
KW - Calcium alginate
KW - Drug release
KW - Hydrogel microbeads
KW - NIR
KW - Near-infrared laser
UR - http://www.scopus.com/inward/record.url?scp=85114963277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85114963277&partnerID=8YFLogxK
U2 - 10.1109/Transducers50396.2021.9495711
DO - 10.1109/Transducers50396.2021.9495711
M3 - Conference contribution
AN - SCOPUS:85114963277
T3 - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
SP - 1000
EP - 1003
BT - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
Y2 - 20 June 2021 through 25 June 2021
ER -