Negative regulation of cytokine signaling influences inflammation

Akihiko Yoshimura, Hiroyuki Mori, Masanobu Ohishi, Daisuke Aki, Toshikatsu Hanada

Research output: Contribution to journalReview articlepeer-review

109 Citations (Scopus)


Inflammation is progressed by the action of pro-inflammatory cytokines, including IL-1, TNF, IFN-γ and IL-6, and is resolved by anti-inflammatory cytokines, such as IL-4, IL-10, IL-13, IFN-α and transforming growth factor-β (TGF-β). Intracellular signal transduction pathways initiated by these cytokines have been studied extensively; these pathways ultimately activate transcription factors, such as NF-κB, Smad and STATs. Recently, negative feedback regulation of these pathways, mediated by molecules such as A-20, Smad7 and CIS/SOCS family proteins, has been identified. Negative regulation of cytokine signaling is quite important for inflammation.

Original languageEnglish
Pages (from-to)704-708
Number of pages5
JournalCurrent Opinion in Immunology
Issue number6
Publication statusPublished - 2003 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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