TY - JOUR
T1 - Negative regulation of cytokine signaling influences inflammation
AU - Yoshimura, Akihiko
AU - Mori, Hiroyuki
AU - Ohishi, Masanobu
AU - Aki, Daisuke
AU - Hanada, Toshikatsu
PY - 2003/12
Y1 - 2003/12
N2 - Inflammation is progressed by the action of pro-inflammatory cytokines, including IL-1, TNF, IFN-γ and IL-6, and is resolved by anti-inflammatory cytokines, such as IL-4, IL-10, IL-13, IFN-α and transforming growth factor-β (TGF-β). Intracellular signal transduction pathways initiated by these cytokines have been studied extensively; these pathways ultimately activate transcription factors, such as NF-κB, Smad and STATs. Recently, negative feedback regulation of these pathways, mediated by molecules such as A-20, Smad7 and CIS/SOCS family proteins, has been identified. Negative regulation of cytokine signaling is quite important for inflammation.
AB - Inflammation is progressed by the action of pro-inflammatory cytokines, including IL-1, TNF, IFN-γ and IL-6, and is resolved by anti-inflammatory cytokines, such as IL-4, IL-10, IL-13, IFN-α and transforming growth factor-β (TGF-β). Intracellular signal transduction pathways initiated by these cytokines have been studied extensively; these pathways ultimately activate transcription factors, such as NF-κB, Smad and STATs. Recently, negative feedback regulation of these pathways, mediated by molecules such as A-20, Smad7 and CIS/SOCS family proteins, has been identified. Negative regulation of cytokine signaling is quite important for inflammation.
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U2 - 10.1016/j.coi.2003.09.004
DO - 10.1016/j.coi.2003.09.004
M3 - Review article
C2 - 14630206
AN - SCOPUS:0242407711
SN - 0952-7915
VL - 15
SP - 704
EP - 708
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -