TY - JOUR
T1 - Neonatal pemphigus vulgaris
T2 - IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns
AU - Parlowsky, Thomas
AU - Welzel, Julia
AU - Amagai, Masayuki
AU - Zillikens, Detlef
AU - Wygold, Thorsten
PY - 2003/4/1
Y1 - 2003/4/1
N2 - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.
AB - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.
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U2 - 10.1067/mjd.2003.170
DO - 10.1067/mjd.2003.170
M3 - Article
C2 - 12664033
AN - SCOPUS:0037380309
SN - 0190-9622
VL - 48
SP - 623
EP - 625
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -