TY - JOUR
T1 - Nephroprotective effect and its mechanism of betamipron (1) —Relationships of renal transport—
AU - Naganuma, Hideo
AU - Tokiwa, Hiroshi
AU - Hirouchi, Yasukuni
AU - Kawahara, Yukinori
AU - Fukami, Masaharu
AU - Fukushige, Jun Ichiro
AU - Hirota, Koji
AU - Muramatsu, Shigeki
AU - Takahagi, Hidekuni
AU - Inui, Ken Ichi
AU - Tanigawara, Yusuke
AU - Yasuhara, Masato
AU - Hori, Ryohei
AU - Kuwahara, Shogo
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Nephroprotective effect of betamipron (BP) and its mechanism were investigated in view of renal transport of panipenem (PAPM), a new carbapenem antibiotic, in rabbits. Concomitant intravenous dose of BP (0.5～2 folds to PAPM) decreased dose-dependently the frequency of renal tubular necrosis caused by more than 150mg/kg of antibiotic administration. The decrement of nephrotoxicity was well correlated with the inhibitory activity of the renal cortical accumulation of PAPM. rhe optimal dose ratio of BP was equivalent to PAPM as weight. Such nephroprotective effect of BP was also observed in rabbits with acute glomerular nephritis. Both of BP and probenecid, an organic anion transport inhibitor, were practically prevented the〔14C〕 PAPM uptake in isolated renal tubule. BP hardly inhibited the rat renal dehydropeptidase- I activity unlike cilastatin. Nontoxic and nephroselective properties of BP might be full of promise to clinical use as a desirable nephroprotective agent for PAPM.
AB - Nephroprotective effect of betamipron (BP) and its mechanism were investigated in view of renal transport of panipenem (PAPM), a new carbapenem antibiotic, in rabbits. Concomitant intravenous dose of BP (0.5～2 folds to PAPM) decreased dose-dependently the frequency of renal tubular necrosis caused by more than 150mg/kg of antibiotic administration. The decrement of nephrotoxicity was well correlated with the inhibitory activity of the renal cortical accumulation of PAPM. rhe optimal dose ratio of BP was equivalent to PAPM as weight. Such nephroprotective effect of BP was also observed in rabbits with acute glomerular nephritis. Both of BP and probenecid, an organic anion transport inhibitor, were practically prevented the〔14C〕 PAPM uptake in isolated renal tubule. BP hardly inhibited the rat renal dehydropeptidase- I activity unlike cilastatin. Nontoxic and nephroselective properties of BP might be full of promise to clinical use as a desirable nephroprotective agent for PAPM.
UR - http://www.scopus.com/inward/record.url?scp=0025998682&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025998682&partnerID=8YFLogxK
U2 - 10.11250/chemotherapy1953.39.Supplement3_166
DO - 10.11250/chemotherapy1953.39.Supplement3_166
M3 - Article
AN - SCOPUS:0025998682
SN - 0009-3165
VL - 39
SP - 166
EP - 177
JO - Chemotherapy
JF - Chemotherapy
ER -
