Nephroprotective effect and its mechanism of betamipron (1) —Relationships of renal transport—

Hideo Naganuma; Hiroshi Tokiwa; Yasukuni Hirouchi; Yukinori Kawahara; Masaharu Fukami; Jun Ichiro Fukushige; Koji Hirota; Shigeki Muramatsu; Hidekuni Takahagi; Ken Ichi Inui; Yusuke Tanigawara; Masato Yasuhara; Ryohei Hori; Shogo Kuwahara

doi:10.11250/chemotherapy1953.39.Supplement3_166

Nephroprotective effect and its mechanism of betamipron (1) —Relationships of renal transport—

Hideo Naganuma
, Hiroshi Tokiwa
, Yasukuni Hirouchi
, Yukinori Kawahara
, Masaharu Fukami
, Jun Ichiro Fukushige
, Koji Hirota
, Shigeki Muramatsu
, Hidekuni Takahagi
, Ken Ichi Inui
, Yusuke Tanigawara
, Masato Yasuhara
, Ryohei Hori
, Shogo Kuwahara

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Nephroprotective effect of betamipron (BP) and its mechanism were investigated in view of renal transport of panipenem (PAPM), a new carbapenem antibiotic, in rabbits. Concomitant intravenous dose of BP (0.5～2 folds to PAPM) decreased dose-dependently the frequency of renal tubular necrosis caused by more than 150mg/kg of antibiotic administration. The decrement of nephrotoxicity was well correlated with the inhibitory activity of the renal cortical accumulation of PAPM. rhe optimal dose ratio of BP was equivalent to PAPM as weight. Such nephroprotective effect of BP was also observed in rabbits with acute glomerular nephritis. Both of BP and probenecid, an organic anion transport inhibitor, were practically prevented the〔¹⁴C〕 PAPM uptake in isolated renal tubule. BP hardly inhibited the rat renal dehydropeptidase- I activity unlike cilastatin. Nontoxic and nephroselective properties of BP might be full of promise to clinical use as a desirable nephroprotective agent for PAPM.

Original language	English
Pages (from-to)	166-177
Number of pages	12
Journal	Chemotherapy
Volume	39
DOIs	https://doi.org/10.11250/chemotherapy1953.39.Supplement3_166
Publication status	Published - 1991 Jan 1
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

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10.11250/chemotherapy1953.39.Supplement3_166

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Naganuma, H., Tokiwa, H., Hirouchi, Y., Kawahara, Y., Fukami, M., Fukushige, J. I., Hirota, K., Muramatsu, S., Takahagi, H., Inui, K. I., Tanigawara, Y., Yasuhara, M., Hori, R., & Kuwahara, S. (1991). Nephroprotective effect and its mechanism of betamipron (1) —Relationships of renal transport—. Chemotherapy, 39, 166-177. https://doi.org/10.11250/chemotherapy1953.39.Supplement3_166

Naganuma, H, Tokiwa, H, Hirouchi, Y, Kawahara, Y, Fukami, M, Fukushige, JI, Hirota, K, Muramatsu, S, Takahagi, H, Inui, KI, Tanigawara, Y, Yasuhara, M, Hori, R & Kuwahara, S 1991, 'Nephroprotective effect and its mechanism of betamipron (1) —Relationships of renal transport—', Chemotherapy, vol. 39, pp. 166-177. https://doi.org/10.11250/chemotherapy1953.39.Supplement3_166

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title = "Nephroprotective effect and its mechanism of betamipron (1) —Relationships of renal transport—",

abstract = "Nephroprotective effect of betamipron (BP) and its mechanism were investigated in view of renal transport of panipenem (PAPM), a new carbapenem antibiotic, in rabbits. Concomitant intravenous dose of BP (0.5～2 folds to PAPM) decreased dose-dependently the frequency of renal tubular necrosis caused by more than 150mg/kg of antibiotic administration. The decrement of nephrotoxicity was well correlated with the inhibitory activity of the renal cortical accumulation of PAPM. rhe optimal dose ratio of BP was equivalent to PAPM as weight. Such nephroprotective effect of BP was also observed in rabbits with acute glomerular nephritis. Both of BP and probenecid, an organic anion transport inhibitor, were practically prevented the〔14C〕 PAPM uptake in isolated renal tubule. BP hardly inhibited the rat renal dehydropeptidase- I activity unlike cilastatin. Nontoxic and nephroselective properties of BP might be full of promise to clinical use as a desirable nephroprotective agent for PAPM.",

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Nephroprotective effect and its mechanism of betamipron (1) —Relationships of renal transport—

Abstract

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