Neuro-immune crosstalk and allergic inflammation

Hiroki Kabata, David Artis

Research output: Contribution to journalArticlepeer-review

111 Citations (Scopus)


The neuronal and immune systems exhibit bidirectional interactions that play a critical role in tissue homeostasis, infection, and inflammation. Neuron-derived neuropeptides and neurotransmitters regulate immune cell functions, whereas inflammatory mediators produced by immune cells enhance neuronal activation. In recent years, accumulating evidence suggests that peripheral neurons and immune cells are colocalized and affect each other in local tissues. A variety of cytokines, inflammatory mediators, neuropeptides, and neurotransmitters appear to facilitate this crosstalk and positive-feedback loops between multiple types of immune cells and the central, peripheral, sympathetic, parasympathetic, and enteric nervous systems. In this Review, we discuss these recent findings regarding neuro-immune crosstalk that are uncovering molecular mechanisms that regulate inflammation. Finally, neuro-immune crosstalk has a key role in the pathophysiology of allergic diseases, and we present evidence indicating that neuro-immune interactions regulate asthma pathophysiology through both direct and indirect mechanisms.

Original languageEnglish
Pages (from-to)1475-1482
Number of pages8
JournalJournal of Clinical Investigation
Issue number4
Publication statusPublished - 2019 Apr 1
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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