Neurotrophic activity in cytokine-activated astrocytes

Kazunari Yoshida, Shigeo Toya

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


Accumulating evidence indicates that various neurotrophic factors (NTFs) exist and function in the brain. In the mature mammalian brain, NTF expression is exclusively restricted to neurons. However, astrocytes activated by various cytokines, including fibroblast growth factor and interleukin-1̄, produce a significant amount of nerve growth factor (NGF) in vitro. Furthermore, non-NGF type NTF expression in astrocytes is also activated by the cytokines. The cytokines also enhance both release of ciliary neurotrophic factor from and expression of high-molecular weight basic fibroblast growth factor (FGF) in astrocytes. In the early phase following brain injury, cytokine-activated astrocytes rescue the damaged neurons via NTFs and other biologically active molecules.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalKeio Journal of Medicine
Issue number2
Publication statusPublished - 1997 Jun


  • Astrocyte
  • Cell adhesion molecule
  • Cytokine
  • Neurotrophic factor

ASJC Scopus subject areas

  • Medicine(all)


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