New 2-(2-phenylethyl)chromone derivatives and inhibitors of phosphodiesterase (PDE) 3A from Agarwood

Takuji Sugiyama; Yuji Narukawa; Shunsuke Shibata; Ryo Masui; Fumiyuk Kiuchi

doi:10.1177/1934578x1601100624

New 2-(2-phenylethyl)chromone derivatives and inhibitors of phosphodiesterase (PDE) 3A from Agarwood

Takuji Sugiyama, Yuji Narukawa, Shunsuke Shibata, Ryo Masui, Fumiyuk Kiuchi

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6, 8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6, 7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.

Original language	English
Pages (from-to)	795-797
Number of pages	3
Journal	Natural product communications
Volume	11
Issue number	6
DOIs	https://doi.org/10.1177/1934578x1601100624
Publication status	Published - 2016 Jun

Keywords

2-(2-Phenylethyl)chromone
Agarwood
Phosphodiesterase inhibitor

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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10.1177/1934578x1601100624

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abstract = "The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6, 8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6, 7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.",

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AU - Sugiyama, Takuji

AU - Narukawa, Yuji

AU - Shibata, Shunsuke

AU - Masui, Ryo

AU - Kiuchi, Fumiyuk

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New 2-(2-phenylethyl)chromone derivatives and inhibitors of phosphodiesterase (PDE) 3A from Agarwood

Abstract

Keywords

ASJC Scopus subject areas

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