New leishmanicidal stilbenes from a peruvian folk medicine, Lonchocarpus nicou

Hiroyuki Fuchino, Fumiyuki Kiuchi, Azusa Yamanaka, Akihiro Obu, Hiroshi Wada, Kanami Mori-Yasumoto, Nobuo Kawahara, Diana Flores, Olga Palacios, Setsuko Sekita, Motoyoshi Satake

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Two new stilbenes, 1 and 2, were isolated as leishmanicidal constituents from the methanolic extract of Lonchocarpus nicou leaves and stem, together with five known stilbenes and rotenoids. Their chemical structures were determined by spectral methods. Among them, the cis stilbene-type compounds 1 and 4 showed potent leishmanicidal activity (IC50: 5.5, 3.9μg/mL), while the trans stilbene-type compounds 2 and 5, and rotenoids 6 and 7, showed moderate activities (IC50: 9.9, 12.8, 22.6, 19.6μg/mL, respectively).

Original languageEnglish
Pages (from-to)979-982
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Issue number9
Publication statusPublished - 2013 Sept
Externally publishedYes


  • Barbasco
  • Leguminosae
  • Leishmania
  • Lonchocarpus nicou
  • Peruvian folk medicine

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery


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