New norditerpenoids with trypanocidal activity from Vitex trifolia

Fumiyuki Kiuchi; Kenji Matsuo; Michiho Ito; Tran Kim Qui; Gisho Honda

doi:10.1248/cpb.52.1492

New norditerpenoids with trypanocidal activity from Vitex trifolia

Fumiyuki Kiuchi, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).

Original language	English
Pages (from-to)	1492-1494
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	12
DOIs	https://doi.org/10.1248/cpb.52.1492
Publication status	Published - 2004 Dec
Externally published	Yes

Keywords

Norditerpene aldehyde
Trypanocidal constituent
Trypanosoma cruzi
Verbenaceae
Vitex trifolia

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.52.1492

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title = "New norditerpenoids with trypanocidal activity from Vitex trifolia",

abstract = "Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).",

keywords = "Norditerpene aldehyde, Trypanocidal constituent, Trypanosoma cruzi, Verbenaceae, Vitex trifolia",

author = "Fumiyuki Kiuchi and Kenji Matsuo and Michiho Ito and Qui, {Tran Kim} and Gisho Honda",

year = "2004",

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AU - Matsuo, Kenji

AU - Ito, Michiho

AU - Qui, Tran Kim

AU - Honda, Gisho

PY - 2004/12

Y1 - 2004/12

N2 - Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 μM (1), 36 μM (2), 34 μM (3), 34 μM (4), 66 μM (5), 66 μM (6), and >265 μM (7).

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KW - Norditerpene aldehyde

KW - Trypanocidal constituent

KW - Trypanosoma cruzi

KW - Verbenaceae

KW - Vitex trifolia

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New norditerpenoids with trypanocidal activity from Vitex trifolia

Abstract

Keywords

ASJC Scopus subject areas

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