New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

Fumiyuki Kiuchi, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

Original languageEnglish
Pages (from-to)1495-1496
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Issue number12
Publication statusPublished - 2004 Dec
Externally publishedYes


  • Labiatae
  • Pogostemon cablin
  • Sesquiterpene hydroperoxide
  • Trypanocidal constitutent
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery


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