New synthesis of (+)-and (-)-nojirimycin from myo-inositol

Noritaka Chida, Yuka Furuno, Seiichiro Ogawa

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27 Citations (Scopus)


A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.

Original languageEnglish
Pages (from-to)1230-1231
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number17
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Molecular Medicine


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