TY - JOUR
T1 - New transcutaneous sampling of glucose for patients with type II diabetes using an ion-sensitive field-effect transistor
AU - Kayashima, Shinsuke
AU - Arai, Tsunenori
AU - Noritake, Masayuki
AU - Nagata, Naokazu
AU - Kikuchi, Makoto
AU - Ito, Narushi
AU - Matsumoto, Yasuyoshi
AU - Kaneyoshi, Akio
AU - Kimura, Jun
AU - Kuriyama, Toshihide
PY - 1995/8/31
Y1 - 1995/8/31
N2 - Blood glucose change during the 75-g oral glucose tolerance test (g OGTT) was monitored by suction effusion fluid (SEF) sampling in five patients with type II diabetes. SEF is a small volume of fluid sampled by sucking the stratum corneum-stripped skin by an absolute pressure of 400 mmHg without bleeding or subcutaneous hemorrhage. Serum glucose and SEF glucose in each 5-μl sample were measured by an ion-sensitive field-effect transistor (ISFET) glucose sensor. The coefficients of determination between the SEF and serum glucose change were between 0.759 and 0.964, and after adjusting sampling delay they became between 0.839 and 0.996, irrespective of the patient's age, diabetic history and diabetic complications. The damage to the sucked skin surface was mild with pressed mesh forms. Transcutaneous monitoring was achieved in diabetic patients with mild skin damage by the SEF sampling method.
AB - Blood glucose change during the 75-g oral glucose tolerance test (g OGTT) was monitored by suction effusion fluid (SEF) sampling in five patients with type II diabetes. SEF is a small volume of fluid sampled by sucking the stratum corneum-stripped skin by an absolute pressure of 400 mmHg without bleeding or subcutaneous hemorrhage. Serum glucose and SEF glucose in each 5-μl sample were measured by an ion-sensitive field-effect transistor (ISFET) glucose sensor. The coefficients of determination between the SEF and serum glucose change were between 0.759 and 0.964, and after adjusting sampling delay they became between 0.839 and 0.996, irrespective of the patient's age, diabetic history and diabetic complications. The damage to the sucked skin surface was mild with pressed mesh forms. Transcutaneous monitoring was achieved in diabetic patients with mild skin damage by the SEF sampling method.
KW - Bio-sensor
KW - Glucose monitoring
KW - Interstitial fluid
KW - Type II diabetes
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U2 - 10.1016/0009-8981(95)06122-5
DO - 10.1016/0009-8981(95)06122-5
M3 - Article
C2 - 8582056
AN - SCOPUS:0029124974
SN - 0009-8981
VL - 240
SP - 11
EP - 19
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 1
ER -
