Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids

Takanori Iwasaki; Kiyokazu Higashikawa; Vutukuri P. Reddy; Willbe W.S. Ho; Yukari Fujimoto; Koichi Fukase; Jun Terao; Hitoshi Kuniyasu; Nobuaki Kambe

doi:10.1002/chem.201204222

Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids

Takanori Iwasaki, Kiyokazu Higashikawa, Vutukuri P. Reddy, Willbe W.S. Ho, Yukari Fujimoto, Koichi Fukase, Jun Terao, Hitoshi Kuniyasu, Nobuaki Kambe

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The knights who say Ni: A practical and convenient synthetic route to fatty acids involves the Ni-catalyzed alkyl-alkyl cross-coupling of bromoalkanoic acids and alkyl Grignard reagents in the presence of 1,3-butadiene as an additive (see scheme).

Original language	English
Pages (from-to)	2956-2960
Number of pages	5
Journal	Chemistry - A European Journal
Volume	19
Issue number	9
DOIs	https://doi.org/10.1002/chem.201204222
Publication status	Published - 2013 Feb 25
Externally published	Yes

Keywords

C-C coupling
additives
alkylation
fatty acids
nickel

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/chem.201204222

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Iwasaki, T., Higashikawa, K., Reddy, V. P., Ho, W. W. S., Fujimoto, Y., Fukase, K., Terao, J., Kuniyasu, H., & Kambe, N. (2013). Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids. Chemistry - A European Journal, 19(9), 2956-2960. https://doi.org/10.1002/chem.201204222

Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids. / Iwasaki, Takanori; Higashikawa, Kiyokazu; Reddy, Vutukuri P. et al.
In: Chemistry - A European Journal, Vol. 19, No. 9, 25.02.2013, p. 2956-2960.

Research output: Contribution to journal › Article › peer-review

Iwasaki, T, Higashikawa, K, Reddy, VP, Ho, WWS, Fujimoto, Y, Fukase, K, Terao, J, Kuniyasu, H & Kambe, N 2013, 'Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids', Chemistry - A European Journal, vol. 19, no. 9, pp. 2956-2960. https://doi.org/10.1002/chem.201204222

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AU - Reddy, Vutukuri P.

AU - Ho, Willbe W.S.

AU - Fujimoto, Yukari

AU - Fukase, Koichi

AU - Terao, Jun

AU - Kuniyasu, Hitoshi

AU - Kambe, Nobuaki

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Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids

Abstract

Keywords

ASJC Scopus subject areas

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