Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids

Takanori Iwasaki; Kiyokazu Higashikawa; Vutukuri P. Reddy; Willbe W.S. Ho; Yukari Fujimoto; Koichi Fukase; Jun Terao; Hitoshi Kuniyasu; Nobuaki Kambe

doi:10.1002/chem.201204222

Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids

Takanori Iwasaki
, Kiyokazu Higashikawa
, Vutukuri P. Reddy
, Willbe W.S. Ho
, Yukari Fujimoto
, Koichi Fukase
, Jun Terao
, Hitoshi Kuniyasu
, Nobuaki Kambe

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The knights who say Ni: A practical and convenient synthetic route to fatty acids involves the Ni-catalyzed alkyl-alkyl cross-coupling of bromoalkanoic acids and alkyl Grignard reagents in the presence of 1,3-butadiene as an additive (see scheme).

Original language	English
Pages (from-to)	2956-2960
Number of pages	5
Journal	Chemistry - A European Journal
Volume	19
Issue number	9
DOIs	https://doi.org/10.1002/chem.201204222
Publication status	Published - 2013 Feb 25
Externally published	Yes

Keywords

C-C coupling
additives
alkylation
fatty acids
nickel

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/chem.201204222

Cite this

Iwasaki, T., Higashikawa, K., Reddy, V. P., Ho, W. W. S., Fujimoto, Y., Fukase, K., Terao, J., Kuniyasu, H., & Kambe, N. (2013). Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids. Chemistry - A European Journal, 19(9), 2956-2960. https://doi.org/10.1002/chem.201204222

Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids. / Iwasaki, Takanori; Higashikawa, Kiyokazu; Reddy, Vutukuri P. et al.
In: Chemistry - A European Journal, Vol. 19, No. 9, 25.02.2013, p. 2956-2960.

Research output: Contribution to journal › Article › peer-review

Iwasaki, T, Higashikawa, K, Reddy, VP, Ho, WWS, Fujimoto, Y, Fukase, K, Terao, J, Kuniyasu, H & Kambe, N 2013, 'Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids', Chemistry - A European Journal, vol. 19, no. 9, pp. 2956-2960. https://doi.org/10.1002/chem.201204222

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keywords = "C-C coupling, additives, alkylation, fatty acids, nickel",

author = "Takanori Iwasaki and Kiyokazu Higashikawa and Reddy, \{Vutukuri P.\} and Ho, \{Willbe W.S.\} and Yukari Fujimoto and Koichi Fukase and Jun Terao and Hitoshi Kuniyasu and Nobuaki Kambe",

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AU - Iwasaki, Takanori

AU - Higashikawa, Kiyokazu

AU - Reddy, Vutukuri P.

AU - Ho, Willbe W.S.

AU - Fujimoto, Yukari

AU - Fukase, Koichi

AU - Terao, Jun

AU - Kuniyasu, Hitoshi

AU - Kambe, Nobuaki

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KW - C-C coupling

KW - additives

KW - alkylation

KW - fatty acids

KW - nickel

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Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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