Nitric oxide production inhibitory activity of flavonoids contained in trunk exudates of Dalbergia sissoo

Suraj Prakash Shrestha; Yuri Amano; Yuji Narukawa; Tadahiro Takeda

doi:10.1021/np070478h

Nitric oxide production inhibitory activity of flavonoids contained in trunk exudates of Dalbergia sissoo

Suraj Prakash Shrestha, Yuri Amano, Yuji Narukawa, Tadahiro Takeda

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Methanolic extracts of trunk exudates of Dalbergia sissoo yielded two new open-chain neoflavonoids (1, 2), a new flavonoid (3), a new flavanone (4), and 26 known compounds. Their structures were elucidated by detailed spectroscopic analyses. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated J774.1 cells was also studied. All of the isolated compounds except 4, formononetin, and zenognosin B exhibited significant activity in a concentration-dependent manner. Compounds 2 and 3 were among the most potent NO production inhibitors, with IC₅₀ values of 3.19 and 6.22 μM, respectively, and compound 1 had an IC₅₀ of 31.6 μM.

Original language	English
Pages (from-to)	98-101
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	1
DOIs	https://doi.org/10.1021/np070478h
Publication status	Published - 2008 Jan

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Methanolic extracts of trunk exudates of Dalbergia sissoo yielded two new open-chain neoflavonoids (1, 2), a new flavonoid (3), a new flavanone (4), and 26 known compounds. Their structures were elucidated by detailed spectroscopic analyses. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated J774.1 cells was also studied. All of the isolated compounds except 4, formononetin, and zenognosin B exhibited significant activity in a concentration-dependent manner. Compounds 2 and 3 were among the most potent NO production inhibitors, with IC50 values of 3.19 and 6.22 μM, respectively, and compound 1 had an IC50 of 31.6 μM.",

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AU - Shrestha, Suraj Prakash

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AU - Narukawa, Yuji

AU - Takeda, Tadahiro

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AB - Methanolic extracts of trunk exudates of Dalbergia sissoo yielded two new open-chain neoflavonoids (1, 2), a new flavonoid (3), a new flavanone (4), and 26 known compounds. Their structures were elucidated by detailed spectroscopic analyses. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated J774.1 cells was also studied. All of the isolated compounds except 4, formononetin, and zenognosin B exhibited significant activity in a concentration-dependent manner. Compounds 2 and 3 were among the most potent NO production inhibitors, with IC50 values of 3.19 and 6.22 μM, respectively, and compound 1 had an IC50 of 31.6 μM.

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Nitric oxide production inhibitory activity of flavonoids contained in trunk exudates of Dalbergia sissoo

Abstract

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