Nitric oxide regulates NMDA-induced dopamine release in rat striatum

Mamoru Shibata, Nobuo Araki, Kouichi Ohta, Junichi Hamada, Kunio Shimazu, Yasuo Fukuuchi

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1 mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of .5 mM N(G)-nitro-L-arginine methyl ester (-NAME), a NO synthase inhibitor, into the striatum significantly potentiated NMDA-induced DA release. This effect of L-NAME was completely reversed in the presence of 50 mM L-arginine (L-Arg). Administration of 1 mM NMDA significantly decreased the levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). This effect of NMDA was not affected by concurrent administration of L-NAME. This study provides in vivo evidence for the involvement of NO in NMDA-induced DA release.

Original languageEnglish
Pages (from-to)605-608
Number of pages4
Issue number2
Publication statusPublished - 1996 Jan 1


  • N-methyl-D-aspartate (NMDA)
  • dihydroxyphenylacetic acid (DOPAC)
  • dopamine (DA)
  • homovanillic acid (HVA)
  • in vivo microdialysis
  • neurotransmitter
  • nitric oxide
  • striatum

ASJC Scopus subject areas

  • General Neuroscience


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