NKT cell frequency in Japanese type 1 diabetes

Yoichi Oikawa; Akira Shimada; Satoru Yamada; Yoshiko Motohashi; Yoshinori Nakagawa; Jun Ichiro Irie; Taro Maruyama; Takao Saruta

doi:10.1196/annals.1288.033

NKT cell frequency in Japanese type 1 diabetes

Yoichi Oikawa, Akira Shimada, Satoru Yamada, Yoshiko Motohashi, Yoshinori Nakagawa, Jun Ichiro Irie, Taro Maruyama, Takao Saruta

Department of Internal Medicine (Nephrology, Endocrinology and Metabolism)

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in Islet-associated Ab+ and Ab- Japanese "classic" type 1 diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.

Original language	English
Pages (from-to)	230-232
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1005
DOIs	https://doi.org/10.1196/annals.1288.033
Publication status	Published - 2003

Keywords

NKT cell
Type 1 diabetes

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1196/annals.1288.033

Cite this

@article{9345d4e7e43e4f5c9a193d2cb3c5097a,

title = "NKT cell frequency in Japanese type 1 diabetes",

abstract = "A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in Islet-associated Ab+ and Ab- Japanese {"}classic{"} type 1 diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab- {"}classic{"} type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.",

keywords = "NKT cell, Type 1 diabetes",

author = "Yoichi Oikawa and Akira Shimada and Satoru Yamada and Yoshiko Motohashi and Yoshinori Nakagawa and Irie, {Jun Ichiro} and Taro Maruyama and Takao Saruta",

year = "2003",

doi = "10.1196/annals.1288.033",

language = "English",

volume = "1005",

pages = "230--232",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - NKT cell frequency in Japanese type 1 diabetes

AU - Oikawa, Yoichi

AU - Shimada, Akira

AU - Yamada, Satoru

AU - Motohashi, Yoshiko

AU - Nakagawa, Yoshinori

AU - Irie, Jun Ichiro

AU - Maruyama, Taro

AU - Saruta, Takao

PY - 2003

Y1 - 2003

N2 - A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in Islet-associated Ab+ and Ab- Japanese "classic" type 1 diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.

AB - A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in Islet-associated Ab+ and Ab- Japanese "classic" type 1 diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.

KW - NKT cell

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=1942539069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1942539069&partnerID=8YFLogxK

U2 - 10.1196/annals.1288.033

DO - 10.1196/annals.1288.033

M3 - Article

C2 - 14679066

AN - SCOPUS:1942539069

SN - 0077-8923

VL - 1005

SP - 230

EP - 232

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

NKT cell frequency in Japanese type 1 diabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this