@inbook{ab9874f7028647e1a051738c6e507f76,
title = "NMR Characterization of the Conformations, Dynamics, and Interactions of Glycosphingolipids",
abstract = "Glycosphingolipids, including gangliosides, can form clusters on membranes and thereby mediate a variety of physiological and pathological functions. This chapter illustrates recent nuclear magnetic resonance (NMR) approaches for elucidating the molecular mechanisms underlying the functional roles of glycosphingolipid clusters, particularly focusing on the conformational dynamics and interactions of gangliosides. Dynamic conformational ensembles of ganglioside glycans in solution have been elucidated using molecular dynamics simulations validated by NMR data. Intermolecular interactions of glycosphingolipids in membrane-like environments have been characterized using solution and solid-state NMR techniques. Various membrane mimics have been developed for NMR studies on the interactions between ganglioside clusters and amyloidogenic proteins associated with neurodegenerative disorders.",
author = "Maho Yagi-Utsumi and Takumi Yamaguchi and Yoshinori Uekusa and Koichi Kato",
note = "Funding Information: We thank Dr Nobuaki Matsumori (Kyushu University) for the useful discussion. We also thank Dr Saeko Yanaka (IMS) for NMR data collection. This study was partly supported by a JSPS/MEXT KAKENHI Grant-in-Aid for Yong Scientists (B) (JP15K21680 to M.Y.-U. and JP15K17889 to T.Y.), Grant-in-Aid for Scientific Research on Innovation Areas (JP25102001 and JP25102008 to K.K.), Grant-in-Aid for Challenging Exploratory Research (JP26560451 to K.K.), Research Funding for Longevity Sciences (25 19) from the National Center for Geriatrics and Gerontology, the Nanotechnology Platform Program of MEXT, and the Okazaki ORION project. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2017.",
year = "2017",
doi = "10.1039/9781782623946-00161",
language = "English",
series = "New Developments in NMR",
publisher = "Royal Society of Chemistry",
number = "10",
pages = "161--178",
editor = "Price, {William S.} and Koichi Kato and Thomas Peters",
booktitle = "Biophysics and Biochemistry of Cartilage by NMR and MRI",
edition = "10",
}