No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome

Sachio Matsushita; Hiroyuki Arai; Takefumi Yuzuriha; Motoichiro Kato; Toshifumi Matsui; Katsuya Urakami; Susumu Higuchi

doi:10.1016/S0197-4580(01)00225-1

No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome

Sachio Matsushita, Hiroyuki Arai, Takefumi Yuzuriha, Motoichiro Kato, Toshifumi Matsui, Katsuya Urakami, Susumu Higuchi

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Among many candidate genes for the genetically heterogeneous Alzheimer's disease (AD), only apolipoprotein E (ApoE) has been confirmed. Another candidate is the dihydrolipoyl succinyltransferase (DLST) gene, one of three components of thiamine-dependent mitochondrial α-ketoglutarate dehydrogenase complex (KGDHC), because KGDHC activity is reported reduced in AD patients. Also characterized by reduced KGDHC activity is another neuropsychiatric disease, Wernicke-Korsakoff syndrome (WKS), which results from thiamine deficiency. Examination of specific DLST gene polymorphism in 247 Japanese AD patients, 53 alcoholic WKS patients, and 368 nondemented Japanese control subjects revealed no significant differences in DLST genotypes and failed to replicate the findings of earlier studies indicating an association between DLST gene polymorphism and AD.

Original language	English
Pages (from-to)	569-574
Number of pages	6
Journal	Neurobiology of Aging
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/S0197-4580(01)00225-1
Publication status	Published - 2001

Keywords

Alzheimer's disease
Apolipoprotein
Dihydrolipoyl succinyltransferase
Polymorphism
Wernicke-Korsakoff syndrome

ASJC Scopus subject areas

Neuroscience(all)
Ageing
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/S0197-4580(01)00225-1

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title = "No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome",

abstract = "Among many candidate genes for the genetically heterogeneous Alzheimer's disease (AD), only apolipoprotein E (ApoE) has been confirmed. Another candidate is the dihydrolipoyl succinyltransferase (DLST) gene, one of three components of thiamine-dependent mitochondrial α-ketoglutarate dehydrogenase complex (KGDHC), because KGDHC activity is reported reduced in AD patients. Also characterized by reduced KGDHC activity is another neuropsychiatric disease, Wernicke-Korsakoff syndrome (WKS), which results from thiamine deficiency. Examination of specific DLST gene polymorphism in 247 Japanese AD patients, 53 alcoholic WKS patients, and 368 nondemented Japanese control subjects revealed no significant differences in DLST genotypes and failed to replicate the findings of earlier studies indicating an association between DLST gene polymorphism and AD.",

keywords = "Alzheimer's disease, Apolipoprotein, Dihydrolipoyl succinyltransferase, Polymorphism, Wernicke-Korsakoff syndrome",

author = "Sachio Matsushita and Hiroyuki Arai and Takefumi Yuzuriha and Motoichiro Kato and Toshifumi Matsui and Katsuya Urakami and Susumu Higuchi",

year = "2001",

doi = "10.1016/S0197-4580(01)00225-1",

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volume = "22",

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T1 - No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome

AU - Matsushita, Sachio

AU - Arai, Hiroyuki

AU - Yuzuriha, Takefumi

AU - Kato, Motoichiro

AU - Matsui, Toshifumi

AU - Urakami, Katsuya

AU - Higuchi, Susumu

PY - 2001

Y1 - 2001

N2 - Among many candidate genes for the genetically heterogeneous Alzheimer's disease (AD), only apolipoprotein E (ApoE) has been confirmed. Another candidate is the dihydrolipoyl succinyltransferase (DLST) gene, one of three components of thiamine-dependent mitochondrial α-ketoglutarate dehydrogenase complex (KGDHC), because KGDHC activity is reported reduced in AD patients. Also characterized by reduced KGDHC activity is another neuropsychiatric disease, Wernicke-Korsakoff syndrome (WKS), which results from thiamine deficiency. Examination of specific DLST gene polymorphism in 247 Japanese AD patients, 53 alcoholic WKS patients, and 368 nondemented Japanese control subjects revealed no significant differences in DLST genotypes and failed to replicate the findings of earlier studies indicating an association between DLST gene polymorphism and AD.

AB - Among many candidate genes for the genetically heterogeneous Alzheimer's disease (AD), only apolipoprotein E (ApoE) has been confirmed. Another candidate is the dihydrolipoyl succinyltransferase (DLST) gene, one of three components of thiamine-dependent mitochondrial α-ketoglutarate dehydrogenase complex (KGDHC), because KGDHC activity is reported reduced in AD patients. Also characterized by reduced KGDHC activity is another neuropsychiatric disease, Wernicke-Korsakoff syndrome (WKS), which results from thiamine deficiency. Examination of specific DLST gene polymorphism in 247 Japanese AD patients, 53 alcoholic WKS patients, and 368 nondemented Japanese control subjects revealed no significant differences in DLST genotypes and failed to replicate the findings of earlier studies indicating an association between DLST gene polymorphism and AD.

KW - Alzheimer's disease

KW - Apolipoprotein

KW - Dihydrolipoyl succinyltransferase

KW - Polymorphism

KW - Wernicke-Korsakoff syndrome

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AN - SCOPUS:0034974005

SN - 0197-4580

VL - 22

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EP - 574

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 4

ER -

No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome

Abstract

Keywords

ASJC Scopus subject areas

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