No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome

Sachio Matsushita, Hiroyuki Arai, Takefumi Yuzuriha, Motoichiro Kato, Toshifumi Matsui, Katsuya Urakami, Susumu Higuchi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Among many candidate genes for the genetically heterogeneous Alzheimer's disease (AD), only apolipoprotein E (ApoE) has been confirmed. Another candidate is the dihydrolipoyl succinyltransferase (DLST) gene, one of three components of thiamine-dependent mitochondrial α-ketoglutarate dehydrogenase complex (KGDHC), because KGDHC activity is reported reduced in AD patients. Also characterized by reduced KGDHC activity is another neuropsychiatric disease, Wernicke-Korsakoff syndrome (WKS), which results from thiamine deficiency. Examination of specific DLST gene polymorphism in 247 Japanese AD patients, 53 alcoholic WKS patients, and 368 nondemented Japanese control subjects revealed no significant differences in DLST genotypes and failed to replicate the findings of earlier studies indicating an association between DLST gene polymorphism and AD.

Original languageEnglish
Pages (from-to)569-574
Number of pages6
JournalNeurobiology of Aging
Issue number4
Publication statusPublished - 2001


  • Alzheimer's disease
  • Apolipoprotein
  • Dihydrolipoyl succinyltransferase
  • Polymorphism
  • Wernicke-Korsakoff syndrome

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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