No association between the CNTF null mutation and schizophrenia or personality

Jun Nishiyama, Mamoru Tochigi, Shin Itoh, Takeshi Otowa, Chieko Kato, Tadashi Umekage, Kazuhisa Kohda, Takashi Ebisawa, Nobumasa Kato, Tsukasa Sasaki

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine that plays a critical role in neurodevelopment. On the basis of neurodevelopmental hypothesis, the CNTF gene has been a candidate locus for schizophrenia. Several studies have investigated the association between the null mutation of the gene and schizophrenia, however, with inconsistent results. In the present study, we investigated the association in 222 Japanese patients with schizophrenia and 237 controls. The association between the mutation and personality traits was also studied, to investigate the effect of the mutation in participants from the general population. As a result, no association was observed between the mutation and schizophrenia nor personality traits, evaluated by using the Revised NEO Personality Inventory scores. The present study did not provide evidence for the association between the CNTF gene and schizophrenia or personality traits in the Japanese population.

Original languageEnglish
Pages (from-to)217-219
Number of pages3
JournalPsychiatric Genetics
Issue number5
Publication statusPublished - 2006 Oct


  • Association study
  • Ciliary neurotrophic factor
  • Mutation
  • Personality traits
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry


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