No cross-resistance of taxotere and taxol to conventional chemotherapeutic agents against gastric cancers as detected by MTT assay

Shingo Maeda; Yoshirou Saikawa; Tetsuro Kubota; Masahiko Aoki; Yoshihide Otani; Toshiharu Furukawa; Masahiko Watanabe; Koichiro Kumai; Masaki Kitajima

No cross-resistance of taxotere and taxol to conventional chemotherapeutic agents against gastric cancers as detected by MTT assay

Shingo Maeda, Yoshirou Saikawa, Tetsuro Kubota, Masahiko Aoki, Yoshihide Otani, Toshiharu Furukawa, Masahiko Watanabe, Koichiro Kumai, Masaki Kitajima

Law School

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

To evaluate the clinical usefulness of taxanes as antitumor agents, we compared the antitumor spectrum of taxanes with those of conventional antitumor agents against 88 fresh gastric cancer specimens by MTT assay. At cut-off concentrations of 100 μ/ml for taxotere (Docetaxel, DOC) and 300/μml for taxol (Paclitaxel, PAC), both agents showed a higher efficacy rate than mitomycin C (MMC), cisplatin (CDDP) and 5-fluorouracil (5-FU) against the gastric cancer specimens. The patterns of antitumor activity of DOC and PAC were independent from those of the conventional agents, while the patterns of antitumor activity of the taxanes significantly correlated with each other. Conventional agent antitumor activity patterns tended to correlate with the patterns of other conventional agents. In conclusion, taxanes may be useful for clinical application against gastric cancer due to their different antitumor spectrum as compared to conventional agents.

Original language	English
Pages (from-to)	3147-3150
Number of pages	4
Journal	Anticancer research
Volume	23
Issue number	4
Publication status	Published - 2003 Jul 1

Keywords

Gastric cancer
MTT assay
Taxol
Taxotere

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "No cross-resistance of taxotere and taxol to conventional chemotherapeutic agents against gastric cancers as detected by MTT assay",

abstract = "To evaluate the clinical usefulness of taxanes as antitumor agents, we compared the antitumor spectrum of taxanes with those of conventional antitumor agents against 88 fresh gastric cancer specimens by MTT assay. At cut-off concentrations of 100 μ/ml for taxotere (Docetaxel, DOC) and 300/μml for taxol (Paclitaxel, PAC), both agents showed a higher efficacy rate than mitomycin C (MMC), cisplatin (CDDP) and 5-fluorouracil (5-FU) against the gastric cancer specimens. The patterns of antitumor activity of DOC and PAC were independent from those of the conventional agents, while the patterns of antitumor activity of the taxanes significantly correlated with each other. Conventional agent antitumor activity patterns tended to correlate with the patterns of other conventional agents. In conclusion, taxanes may be useful for clinical application against gastric cancer due to their different antitumor spectrum as compared to conventional agents.",

keywords = "Gastric cancer, MTT assay, Taxol, Taxotere",

author = "Shingo Maeda and Yoshirou Saikawa and Tetsuro Kubota and Masahiko Aoki and Yoshihide Otani and Toshiharu Furukawa and Masahiko Watanabe and Koichiro Kumai and Masaki Kitajima",

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TY - JOUR

T1 - No cross-resistance of taxotere and taxol to conventional chemotherapeutic agents against gastric cancers as detected by MTT assay

AU - Maeda, Shingo

AU - Saikawa, Yoshirou

AU - Kubota, Tetsuro

AU - Aoki, Masahiko

AU - Otani, Yoshihide

AU - Furukawa, Toshiharu

AU - Watanabe, Masahiko

AU - Kumai, Koichiro

AU - Kitajima, Masaki

PY - 2003/7/1

Y1 - 2003/7/1

N2 - To evaluate the clinical usefulness of taxanes as antitumor agents, we compared the antitumor spectrum of taxanes with those of conventional antitumor agents against 88 fresh gastric cancer specimens by MTT assay. At cut-off concentrations of 100 μ/ml for taxotere (Docetaxel, DOC) and 300/μml for taxol (Paclitaxel, PAC), both agents showed a higher efficacy rate than mitomycin C (MMC), cisplatin (CDDP) and 5-fluorouracil (5-FU) against the gastric cancer specimens. The patterns of antitumor activity of DOC and PAC were independent from those of the conventional agents, while the patterns of antitumor activity of the taxanes significantly correlated with each other. Conventional agent antitumor activity patterns tended to correlate with the patterns of other conventional agents. In conclusion, taxanes may be useful for clinical application against gastric cancer due to their different antitumor spectrum as compared to conventional agents.

AB - To evaluate the clinical usefulness of taxanes as antitumor agents, we compared the antitumor spectrum of taxanes with those of conventional antitumor agents against 88 fresh gastric cancer specimens by MTT assay. At cut-off concentrations of 100 μ/ml for taxotere (Docetaxel, DOC) and 300/μml for taxol (Paclitaxel, PAC), both agents showed a higher efficacy rate than mitomycin C (MMC), cisplatin (CDDP) and 5-fluorouracil (5-FU) against the gastric cancer specimens. The patterns of antitumor activity of DOC and PAC were independent from those of the conventional agents, while the patterns of antitumor activity of the taxanes significantly correlated with each other. Conventional agent antitumor activity patterns tended to correlate with the patterns of other conventional agents. In conclusion, taxanes may be useful for clinical application against gastric cancer due to their different antitumor spectrum as compared to conventional agents.

KW - Gastric cancer

KW - MTT assay

KW - Taxol

KW - Taxotere

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AN - SCOPUS:0041528193

SN - 0250-7005

VL - 23

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JO - Anticancer research

JF - Anticancer research

IS - 4

ER -

No cross-resistance of taxotere and taxol to conventional chemotherapeutic agents against gastric cancers as detected by MTT assay

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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