Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

Muh Chyi Chai, Jun Kohyama

Research output: Contribution to journalShort surveypeer-review

12 Citations (Scopus)


Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

Original languageEnglish
Pages (from-to)183-185
Number of pages3
JournalStem cell reports
Issue number2
Publication statusPublished - 2019 Feb 12

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology


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