Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

Muh Chyi Chai; Jun Kohyama

doi:10.1016/j.stemcr.2019.01.011

Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

Muh Chyi Chai, Jun Kohyama

Department of Physiology

Research output: Contribution to journal › Short survey › peer-review

12 Citations (Scopus)

Abstract

Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

Original language	English
Pages (from-to)	183-185
Number of pages	3
Journal	Stem cell reports
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.stemcr.2019.01.011
Publication status	Published - 2019 Feb 12

ASJC Scopus subject areas

Biochemistry
Genetics
Developmental Biology
Cell Biology

Access to Document

10.1016/j.stemcr.2019.01.011

Cite this

@article{7c8bd4edc150451cafc1b2d97b923c9d,

title = "Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein",

abstract = "Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).",

author = "Chai, {Muh Chyi} and Jun Kohyama",

note = "Funding Information: J.K. is supported by the Japan Agency for Medical Research and Development (AMED) under grant number 18bm0404022h0001 . Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = feb,

day = "12",

doi = "10.1016/j.stemcr.2019.01.011",

language = "English",

volume = "12",

pages = "183--185",

journal = "Stem cell reports",

issn = "2213-6711",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

AU - Chai, Muh Chyi

AU - Kohyama, Jun

PY - 2019/2/12

Y1 - 2019/2/12

N2 - Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

AB - Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson's disease (PD).

UR - http://www.scopus.com/inward/record.url?scp=85060333027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060333027&partnerID=8YFLogxK

U2 - 10.1016/j.stemcr.2019.01.011

DO - 10.1016/j.stemcr.2019.01.011

M3 - Short survey

C2 - 30759377

AN - SCOPUS:85060333027

SN - 2213-6711

VL - 12

SP - 183

EP - 185

JO - Stem cell reports

JF - Stem cell reports

IS - 2

ER -

Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this