Abstract
Incubation of (25iRS)-, (25R)- and (25S)-3α, 7α, 12v-trihydroxy-5β-cholestan-26-oic acid (THCA, 6, 6a, 6b) and (24E)-3α, 7α, 12α-trihydroxy-5β-cholest-24-en-26-oic acid (7) with rat liver mitochondria gave all four stereoisomers (9a, 9b, 9c, 9d) of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic acid (TeHCA). The corresponding 27-nor analogs (10, 11) were also converted non-stereoselectively to a 1:1 mixture of the epimeric 24-hydroxy compounds (12).
| Original language | English |
|---|---|
| Pages (from-to) | 1028-1035 |
| Number of pages | 8 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 42 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1994 Jan 1 |
Keywords
- 12α
- 12α
- 12α
- 24-tetrahydroxy- 5β
- 24-trihydroxy-5β
- 7α
- 7α
- 7α
- bile acid cholic acid β
- cholest-24-en-26-oic acid
- cholestan-26-oic acid 3α
- cholestan-26-oic acid 3α
- oxidation 3α
- trihydroxy-5β
ASJC Scopus subject areas
- General Chemistry
- Drug Discovery
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