Noncoding RNAs in cardiovascular disease

Masaharu Kataoka, Da Zhi Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)


For decades, it has been recognized that proteins, which are encoded by our genomes via transcription and translation, are building blocks that play vital roles in almost all biological processes. Mutations identified in many proteincoding genes are linked to various human diseases. However, this "proteincentered" dogma has been challenged in recent years with the discovery that majority of our genome is "noncoding" yet transcribed. Noncoding RNA has become the focus of "next generation" biology. Here, we review the emerging field of noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), and their function in cardiovascular biology and disease.

Original languageEnglish
Title of host publicationEtiology and Morphogenesis of Congenital Heart Disease
Subtitle of host publicationFrom Gene Function and Cellular Interaction to Morphology
PublisherSpringer Japan
Number of pages5
ISBN (Electronic)9784431546283
ISBN (Print)9784431546276
Publication statusPublished - 2016 Jan 1
Externally publishedYes


  • Cardiac disease
  • Heart development
  • Long noncoding RNAs
  • MicroRNAs

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry,Genetics and Molecular Biology


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