Nondissociative chain walking as a strategy in catalytic organic synthesis

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58 Citations (Scopus)


“Nondissociative” chain walking is a mechanism where an alkylmetal species undergoes rapid β-hydride elimination and reinsertion to move the metal center along the alkyl chain without dissociating an alkene intermediate during the migration process. This digest summarizes the unique characteristics of the nondissociative chain walking mechanism compared to the stepwise alkene isomerization mechanism and their use in catalytic organic synthesis.

Original languageEnglish
Article number150938
JournalTetrahedron Letters
Issue number37
Publication statusPublished - 2019 Sept 12


  • Isomerization
  • Metal catalysis
  • Nondissociative chain walking
  • Remote functionalization

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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