Noninvasive positive pressure ventilation for acute respiratory distress syndrome

Sadatomo Tasaka

Research output: Contribution to journalArticlepeer-review


Invasive mechanical ventilation with positive pressure forms the mainstay of ventilatory support in acute respiratory syndrome (ARDS). Although NPPV is increasingly used in patients with ARDS, a metaanalysis has shown a success rate as low as 50%, which suggests a need for careful introduction of NPPV for the treatment of ARDS. NPPV often fails in ARDS patients with severe illness. In case the oxygenation index is not improved after 1 hour of NPPV, invasive mechanical ventilation should be initiated. In patients with severe pneumonia, NPPV is not routinely recommended. However, among patients with chronic obstructive pulmonary disease, NPPV is associated with a better outcome for acute respiratory failure caused by severe pneumonia.

Original languageEnglish
Pages (from-to)607-614
Number of pages8
JournalJapanese Journal of Chest Diseases
Issue number6
Publication statusPublished - 2016 Jun 1
Externally publishedYes


  • Acute respiratory distress syndrome
  • Acute respiratory failure
  • Influenza
  • Noninvasive positive pressure ventilation
  • Severe pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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